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编 号：F372094
分子式：C13H17N3O4S
分子量：311.36
分子式：C13H17N3O4S
分子量：311.36
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CAS No: 50567-35-6
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生物活性：
Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
体内研究：
Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity.Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents.Animal Model:Male Swiss albino mice (6 weeks old, 25-40 g)
Dosage:100 mg/kg
Administration:Intraperitoneal injection; once
Result:Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.
Animal Model:Male Swiss albino mice (6 weeks old, 25-40 g)
Dosage:100 mg/kg
Administration:Intraperitoneal injection; once
Result:Induced reduction in hepatic glutathione (GSH) content in mice.
Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
体内研究：
Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity.Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents.Animal Model:Male Swiss albino mice (6 weeks old, 25-40 g)
Dosage:100 mg/kg
Administration:Intraperitoneal injection; once
Result:Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.
Animal Model:Male Swiss albino mice (6 weeks old, 25-40 g)
Dosage:100 mg/kg
Administration:Intraperitoneal injection; once
Result:Induced reduction in hepatic glutathione (GSH) content in mice.
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