产品
编 号：F371863
分子式：C25H28O3
分子量：376.49
分子式：C25H28O3
分子量：376.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
400
In-stock
结构图
CAS No: 50-50-0
产品详情
生物活性：
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice.
体内研究：
Estradiol benzoate (20-100 μg/kg, Subcutaneous injection, once a day for 4-5 weeks) 改善 Ovx 雌性小鼠的学习记忆行为。Estradiol benzoate (0.015-15000 μg/kg, Subcutaneous injection, single dose) 使雄性 SD 大鼠的青春期提前。Animal Model:Ovx mice
Dosage:20, 100 or 200 μg/kg
Administration:Subcutaneous injection (s.c.)
Result:Significantly reversed the lowered uterine weight induced by Ovx.Had no obvious effects on locomotor activity in Ovx mice.Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx.Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).
体外研究：
Estradiol benzoate (5-75 μM, 24 h-48 h) 对 SBHX21 细胞中 HBV 的翻译、转录和复制有下调作用。Estradiol benzoate (0-500 μM, 72 h) 对人包皮成纤维细胞 (HFFs) 有毒性。
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice.
体内研究：
Estradiol benzoate (20-100 μg/kg, Subcutaneous injection, once a day for 4-5 weeks) 改善 Ovx 雌性小鼠的学习记忆行为。Estradiol benzoate (0.015-15000 μg/kg, Subcutaneous injection, single dose) 使雄性 SD 大鼠的青春期提前。Animal Model:Ovx mice
Dosage:20, 100 or 200 μg/kg
Administration:Subcutaneous injection (s.c.)
Result:Significantly reversed the lowered uterine weight induced by Ovx.Had no obvious effects on locomotor activity in Ovx mice.Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx.Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).
体外研究：
Estradiol benzoate (5-75 μM, 24 h-48 h) 对 SBHX21 细胞中 HBV 的翻译、转录和复制有下调作用。Estradiol benzoate (0-500 μM, 72 h) 对人包皮成纤维细胞 (HFFs) 有毒性。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备