产品
编 号：F041772
分子式：C5H21N2O6PS
分子量：268.27
分子式：C5H21N2O6PS
分子量：268.27
产品类型
规格
价格
是否有货
5mg
251
In-stock
10mg
402
In-stock
50mg
1689
In-stock
结构图
CAS No: 112901-68-5
产品详情
生物活性：
Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action.
体内研究：
Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice.Animal Model:Male C57BL/6 mice with myocardial I/R injury
Dosage:400 mg/kg
Administration:Intravenous injection; 4 hours
Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
体外研究：
Amifostine (0.78125-100?μM, 24 h)trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM.
Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action.
体内研究：
Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice.Animal Model:Male C57BL/6 mice with myocardial I/R injury
Dosage:400 mg/kg
Administration:Intravenous injection; 4 hours
Result:Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.Significantly reduced the expression of cleaved caspase 3 and Bax whileenhanced the expression of SOD1, SOD2 and Bcl2.Significantly increased SOD activity and reduced MDA levels.
体外研究：
Amifostine (0.78125-100?μM, 24 h)trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备