产品
编 号：F371623
分子式：C32H36ClNO8
分子量：598.08
分子式：C32H36ClNO8
分子量：598.08
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
1g
询价
询价
5g
询价
询价
结构图
CAS No: 50-41-9
产品详情
生物活性：
Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment.
体内研究：
Clomiphene citrate (25-100 mg/kg，腹腔注射，单剂量) 诱导小鼠中期 II 卵母细胞染色体异常。Clomiphene citrate (1 mg/kg，口服，每天 1 次，连续 15 天) 联合 carvedilol (HY-B0006) 对 letrozole (HY-14248) 诱导的多囊卵巢综合征 (PCOS) 大鼠具有抗焦虑潜能和改善认知功能。Animal Model:Female ICR mice
Dosage:25 mg/kg, 50mg/kg, 100mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Resulted in a decrease in the number of ovulated oocytes and a significant increase in hyperploidy at 100 mg/kg.
Animal Model:letrozole(HY-14248)-induced PCOS rats
Dosage:1 mg/kg
Administration:Oral
Result:Demonstrated a statistically raised NRF-2 gene expression.Up-regulated expression of NF-κB.Showed a reversal of the memory defect.Down-regulated of acetylcholine esterase expression.
体外研究：
Clomiphene citrate (50 μM, 1-30 min) 抑制人前列腺癌细胞 PC3 的活性。Clomiphene citrate (1-5 μg/mL, 18 h) 诱导小鼠卵母细胞染色体异常。
Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment.
体内研究：
Clomiphene citrate (25-100 mg/kg，腹腔注射，单剂量) 诱导小鼠中期 II 卵母细胞染色体异常。Clomiphene citrate (1 mg/kg，口服，每天 1 次，连续 15 天) 联合 carvedilol (HY-B0006) 对 letrozole (HY-14248) 诱导的多囊卵巢综合征 (PCOS) 大鼠具有抗焦虑潜能和改善认知功能。Animal Model:Female ICR mice
Dosage:25 mg/kg, 50mg/kg, 100mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Resulted in a decrease in the number of ovulated oocytes and a significant increase in hyperploidy at 100 mg/kg.
Animal Model:letrozole(HY-14248)-induced PCOS rats
Dosage:1 mg/kg
Administration:Oral
Result:Demonstrated a statistically raised NRF-2 gene expression.Up-regulated expression of NF-κB.Showed a reversal of the memory defect.Down-regulated of acetylcholine esterase expression.
体外研究：
Clomiphene citrate (50 μM, 1-30 min) 抑制人前列腺癌细胞 PC3 的活性。Clomiphene citrate (1-5 μg/mL, 18 h) 诱导小鼠卵母细胞染色体异常。
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