产品
编 号：F371515
分子式：C15H27N5O6
分子量：373.4
分子式：C15H27N5O6
分子量：373.4
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CAS No: 503844-09-5
产品详情
生物活性：
EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis.
体内研究：
EA-230 (30-50 mg/kg; i.p.; twice daily for four consecutive days) improves survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation.Animal Model:Male C57Bl/6 mice, ischemia reperfusion injury model
Dosage:20, 30, 40 or 50 mg/kg
Administration:Intraperitoneal injection, twice daily for four consecutive days
Result:Improved survival markedly. With doses between 30–50 mg/kg survival reached 56–62%, the low dose treatment with 20 mg/kg did not have a beneficial effect. Significantly increased renal blood flow (RBF), attenuated CTGF up-regulation, enhanced tubular epithelial cell regeneration and attenuated TGF-beta activation.
EA-230 is a synthetic oligopeptide originally derived from beta-human chorionic gonadotropin (beta-hCG) lysates. EA-230 has anti-inflammatory effects and can be used for the research of sepsis.
体内研究：
EA-230 (30-50 mg/kg; i.p.; twice daily for four consecutive days) improves survival and attenuate loss of kidney function in a mouse model of renal ischemia/reperfusion injury (IRI) and ischemia-induced delayed graft function after allogenic kidney transplantation.Animal Model:Male C57Bl/6 mice, ischemia reperfusion injury model
Dosage:20, 30, 40 or 50 mg/kg
Administration:Intraperitoneal injection, twice daily for four consecutive days
Result:Improved survival markedly. With doses between 30–50 mg/kg survival reached 56–62%, the low dose treatment with 20 mg/kg did not have a beneficial effect. Significantly increased renal blood flow (RBF), attenuated CTGF up-regulation, enhanced tubular epithelial cell regeneration and attenuated TGF-beta activation.
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