产品
编 号：F004713
分子式：C60H76N12O16
分子量：1221.32
分子式：C60H76N12O16
分子量：1221.32
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CAS No: 100940-65-6
产品详情
生物活性：
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.
体内研究：
Sandramycin (0.0125-1.6?mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice.Animal Model:CDF1 female mice injected with leukemia P388 cells
Dosage:0.0125?mg/kg, 0.025?mg/kg, 0.05?mg/kg, 0.1?mg/kg, 0.2?mg/kg, 0.4?mg/kg, 0.8?mg/kg, 1.6?mg/kg
Administration:Intraperitoneal injection; daily; for 5 days
Result:Was moderately active in vivo against leukemia P388 in mice.
体外研究：
Sandramycin has antimicrobial activity wtih MIC values of0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively.Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.
体内研究：
Sandramycin (0.0125-1.6?mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice.Animal Model:CDF1 female mice injected with leukemia P388 cells
Dosage:0.0125?mg/kg, 0.025?mg/kg, 0.05?mg/kg, 0.1?mg/kg, 0.2?mg/kg, 0.4?mg/kg, 0.8?mg/kg, 1.6?mg/kg
Administration:Intraperitoneal injection; daily; for 5 days
Result:Was moderately active in vivo against leukemia P388 in mice.
体外研究：
Sandramycin has antimicrobial activity wtih MIC values of0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively.Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.
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