产品
编 号:F371292
分子式:C23H30BrNO3
分子量:448.39
产品类型
结构图
CAS No: 50-34-0
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产品详情
生物活性:
Propantheline bromide is an orally active mAChR antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination.
体内研究:
Propantheline bromide (口服给药,10-300 mg/kg) 可降低束缚应激性肠功能障碍大鼠的粪便颗粒数和腹泻发生率。Animal Model:Restraint stress-induced bowel dysfunction models in rats
Dosage:10-300 mg/kg
Administration:Oral administration
Result:Decreased the fecal pellet count with ED50 values of 41 mg/kg.Dose-dependently decreased the incidences of diarrhea with ED50 values of 64 mg/kg.
体外研究:
Propantheline bromide (10 μM-1 mM) 降低膀胱平滑肌对乙酰胆碱的反应性。