产品
编 号：F041723
分子式：C27H33ClFN3O10
分子量：614.02
分子式：C27H33ClFN3O10
分子量：614.02
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
184
In-stock
10mg
296
In-stock
50mg
1005
In-stock
结构图
CAS No: 112885-42-4
产品详情
生物活性：
Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases.
体内研究：
Mosapride citrate (0.3-3 mg/kg 或30 mg/kg , 口服) 促进大鼠胃排空，呈剂量依赖性。剂量为 30 mg/kg 时显著抑制大鼠胃排空。Mosapride citrate (0.25, 0.5, 0.75 mg/kg,口服) 在大鼠中可通过激活 5-HT4 受体来减轻非甾体抗炎药诱导的溃疡。Animal Model:NSAID-induced experimental ulcer model
Dosage:0.25, 0.5 , 0.75 mg/kg
Administration:p.o
Result:Inhibited the mucosal damage.
体外研究：
Mosapride citrate (1-100 nM) 显著增加了豚鼠结肠近端和远端收缩的平均幅度，缩短了结肠近端和远端转运时间。Mosapride citrate (869 ng/mL, 48 h) 在人肝细胞 (HMC424, 478 和 493) 中增加 Cytochrome P450 (CYP1A2、2B6和3A4) 的诱导能力。
Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases.
体内研究：
Mosapride citrate (0.3-3 mg/kg 或30 mg/kg , 口服) 促进大鼠胃排空，呈剂量依赖性。剂量为 30 mg/kg 时显著抑制大鼠胃排空。Mosapride citrate (0.25, 0.5, 0.75 mg/kg,口服) 在大鼠中可通过激活 5-HT4 受体来减轻非甾体抗炎药诱导的溃疡。Animal Model:NSAID-induced experimental ulcer model
Dosage:0.25, 0.5 , 0.75 mg/kg
Administration:p.o
Result:Inhibited the mucosal damage.
体外研究：
Mosapride citrate (1-100 nM) 显著增加了豚鼠结肠近端和远端收缩的平均幅度，缩短了结肠近端和远端转运时间。Mosapride citrate (869 ng/mL, 48 h) 在人肝细胞 (HMC424, 478 和 493) 中增加 Cytochrome P450 (CYP1A2、2B6和3A4) 的诱导能力。
产品资料
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