产品
编 号：F370581
分子式：C14H22N2O3
分子量：266.34
分子式：C14H22N2O3
分子量：266.34
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 5011-34-7
产品详情
生物活性：
Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
体内研究：
Trimetazidine (5 -20 mg/kg；口服给药；1 小时；瑞士白化雄性小鼠) 以 10 和 20 mg/kg 的剂量显著提高小鼠 ICES 试验中的癫痫发作阈值电流。Animal Model:Swiss albino male mice (24-35 g)
Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg;10 mL/kg body weight
Administration:Oral administration ; 1 hour
Result:In 10 and 20mg/kg doses significantly raised the seizure-threshold current in the ICES test.
体外研究：
Trimetazidine (1-100 μM；24 h；HUVECs) 以一定的剂量依赖方式增强氧化诱导损伤的 HUVECs 的活力。
Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.
体内研究：
Trimetazidine (5 -20 mg/kg；口服给药；1 小时；瑞士白化雄性小鼠) 以 10 和 20 mg/kg 的剂量显著提高小鼠 ICES 试验中的癫痫发作阈值电流。Animal Model:Swiss albino male mice (24-35 g)
Dosage:5 mg/kg, 10 mg/kg and 20 mg/kg;10 mL/kg body weight
Administration:Oral administration ; 1 hour
Result:In 10 and 20mg/kg doses significantly raised the seizure-threshold current in the ICES test.
体外研究：
Trimetazidine (1-100 μM；24 h；HUVECs) 以一定的剂量依赖方式增强氧化诱导损伤的 HUVECs 的活力。
产品资料
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