产品
编 号：F370181
分子式：C32H44F3N3O2S
分子量：591.77
分子式：C32H44F3N3O2S
分子量：591.77
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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50mg
询价
询价
100mg
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询价
结构图
CAS No: 5002-47-1
产品详情
生物活性：
Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research.
体内研究：
Fluphenazine decanoate (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment.Fluphenazine decanoate (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia.Fluphenazine decanoate (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat.Animal Model:Cebus apella monkey
Dosage:0.22 mg/kg and followed by 0.33 mg/kg
Administration:Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result:Decreased the aggressiveness composite behavioral variables (CBV). Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.
Animal Model:Male Sprague-Dawley rats (250 g)
Dosage:25 mg/kg
Administration:Intramuscular injection into the hind limb; 24 weeks
Result:Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.
Animal Model:Adult male rats
Dosage:1, 2, 3 mg/kg/d
Administration:Subcutaneous injection between 10:00-12:00 h; 60 days
Result:Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.
体外研究：
Fluphenazine decanoate shows activity against T. gondii in human fibroblast cell cultures with an IC50 value of 1.7 mM.
Fluphenazine decanoate is a dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research.
体内研究：
Fluphenazine decanoate (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment.Fluphenazine decanoate (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia.Fluphenazine decanoate (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat.Animal Model:Cebus apella monkey
Dosage:0.22 mg/kg and followed by 0.33 mg/kg
Administration:Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result:Decreased the aggressiveness composite behavioral variables (CBV). Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.
Animal Model:Male Sprague-Dawley rats (250 g)
Dosage:25 mg/kg
Administration:Intramuscular injection into the hind limb; 24 weeks
Result:Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.
Animal Model:Adult male rats
Dosage:1, 2, 3 mg/kg/d
Administration:Subcutaneous injection between 10:00-12:00 h; 60 days
Result:Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.
体外研究：
Fluphenazine decanoate shows activity against T. gondii in human fibroblast cell cultures with an IC50 value of 1.7 mM.
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