产品
编 号：F369763
分子式：C13H13ClN2O
分子量：248.71
分子式：C13H13ClN2O
分子量：248.71
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
384
In-stock
10mg
512
In-stock
25mg
880
In-stock
50mg
1520
In-stock
100mg
询价
询价
结构图
CAS No: 49843-98-3
产品详情
生物活性：
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.
体内研究：
Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
体外研究：
Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.
体内研究：
Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
体外研究：
Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
产品资料
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