产品
编 号：F369691
分子式：C9H10O3
分子量：166.17
分子式：C9H10O3
分子量：166.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
280
In-stock
1g
320
In-stock
5g
640
In-stock
结构图
CAS No: 498-02-2
产品详情
生物活性：
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
体内研究：
Apocynin (0.1 mg/kg/天，腹腔注射，每周 3 次，持续 3 个月) 在 SAMP6小鼠中增加骨矿物质密度和总骨量。Apocynin (5 mg/kg，腹腔注射) 可降低 Carrageenan (HY-125474) 诱导的胸膜炎小鼠的肺损伤程度，减轻急性炎症程度。Animal Model:SAMP6 mouse model (Pharmacokinetic assay)
Dosage:0.1 mg/kg/day
Administration:Intraperitoneal injection (i.p.), three times per week, for 3 months
Result:Showed a higher bone value and exhibited a lower percentage of SA-β -gal positive cells than the control group. Increased the expression of Ki67 and Oct-4 mRNA. Altered the osteoblast-osteoclast balance in bone and promoted the activity of osteoblasts.
Animal Model:Carrageenan (HY-125474)-induced pleurisy in male adult CD1 mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Blocked NADPH oxidase activation and attenuated neutrophil infiltration and lipid peroxidation in the lung tissue. Reduced the degree of PARP activation and the degree of IL-1b expression. Prevented carrageenan-induced IkB-a degradation and reduced the levels of NF-kB p65. Attenuated this iNOS expression,reduced the degree of positive staining for Fas ligand in the lung tissues. Inhibited cells apoptosis in carrageenan-treated mice. Prevented Bax expression and reduced the degree of positive staining for Bax. Attenuated carrageenan-induced inhibition of Bcl-2 expression and the loss of positive staining for Bcl-2 in mice subjected to carrageenan-induced pleurisy. Reduced the level of pERK1/2 and p38 expression.
体外研究：
Apocynin (100 μM，1-7，14 天) 在诱导成骨后，使老化 BMSC 细胞中的成骨标记物表达水平显著增加。Apocynin (1，10，100 μM；48 小时) 选择性抑制 v-H-ras 转染的 3Y1 细胞的增殖和对纤维连接蛋白的粘附。Apocynin (1，10，100 μM；3，6，12 小时) 降低 HR-3Y1-2 细胞而非 3Y1 细胞的细胞内活性氧（ROS）水平。
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
体内研究：
Apocynin (0.1 mg/kg/天，腹腔注射，每周 3 次，持续 3 个月) 在 SAMP6小鼠中增加骨矿物质密度和总骨量。Apocynin (5 mg/kg，腹腔注射) 可降低 Carrageenan (HY-125474) 诱导的胸膜炎小鼠的肺损伤程度，减轻急性炎症程度。Animal Model:SAMP6 mouse model (Pharmacokinetic assay)
Dosage:0.1 mg/kg/day
Administration:Intraperitoneal injection (i.p.), three times per week, for 3 months
Result:Showed a higher bone value and exhibited a lower percentage of SA-β -gal positive cells than the control group. Increased the expression of Ki67 and Oct-4 mRNA. Altered the osteoblast-osteoclast balance in bone and promoted the activity of osteoblasts.
Animal Model:Carrageenan (HY-125474)-induced pleurisy in male adult CD1 mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Blocked NADPH oxidase activation and attenuated neutrophil infiltration and lipid peroxidation in the lung tissue. Reduced the degree of PARP activation and the degree of IL-1b expression. Prevented carrageenan-induced IkB-a degradation and reduced the levels of NF-kB p65. Attenuated this iNOS expression,reduced the degree of positive staining for Fas ligand in the lung tissues. Inhibited cells apoptosis in carrageenan-treated mice. Prevented Bax expression and reduced the degree of positive staining for Bax. Attenuated carrageenan-induced inhibition of Bcl-2 expression and the loss of positive staining for Bcl-2 in mice subjected to carrageenan-induced pleurisy. Reduced the level of pERK1/2 and p38 expression.
体外研究：
Apocynin (100 μM，1-7，14 天) 在诱导成骨后，使老化 BMSC 细胞中的成骨标记物表达水平显著增加。Apocynin (1，10，100 μM；48 小时) 选择性抑制 v-H-ras 转染的 3Y1 细胞的增殖和对纤维连接蛋白的粘附。Apocynin (1，10，100 μM；3，6，12 小时) 降低 HR-3Y1-2 细胞而非 3Y1 细胞的细胞内活性氧（ROS）水平。
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