产品
编 号：F369534
分子式：C18H24ClNO3
分子量：337.84
分子式：C18H24ClNO3
分子量：337.84
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
893
In-stock
结构图
CAS No: 49745-95-1
产品详情
生物活性：
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine hydrochloride has a rapid onset of action and a short half-life .?Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.?Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.?Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.?Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.?Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine hydrochloride has a rapid onset of action and a short half-life .?Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.?Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.?Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.?Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.?Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
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