产品
编 号：F369511
分子式：C9H15N3O2S
分子量：229.3
分子式：C9H15N3O2S
分子量：229.3
产品类型
规格
价格
是否有货
1mg
216
In-stock
5mg
475
In-stock
10mg
760
In-stock
25mg
1520
In-stock
50mg
2920
In-stock
结构图
CAS No: 497-30-3
产品详情
生物活性：
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity.
体内研究：
Ergothioneine (70 mg/kg, 口服, 连续 14 天) 在大鼠中通过调节 Nrf2、p53 和 NF-κB 信号和抑制 γ-谷氨酰转肽酶介导顺铂引起的肾毒性的改善作用。Animal Model:Cisplatin-treated rats
Dosage:70 mg/kg
Administration:p.o. For 14 consecutive days
Result:Decreased serum creatinine and BUN.Increased GFR at two-fold.Suppressed cisplatin-induced oxidative stress and GCT.Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines.
体外研究：
Ergothioneine (0.25, 1 mM, 23 h) 对过氧化氢诱导的 PC12 DNA 损伤、MAPKs 激活和细胞死亡有调节作用。
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity.
体内研究：
Ergothioneine (70 mg/kg, 口服, 连续 14 天) 在大鼠中通过调节 Nrf2、p53 和 NF-κB 信号和抑制 γ-谷氨酰转肽酶介导顺铂引起的肾毒性的改善作用。Animal Model:Cisplatin-treated rats
Dosage:70 mg/kg
Administration:p.o. For 14 consecutive days
Result:Decreased serum creatinine and BUN.Increased GFR at two-fold.Suppressed cisplatin-induced oxidative stress and GCT.Up-regulated the levels of Nrf2, NQO1, and HO-1. Suppresses NF-κB signaling and the pro-inflammatory cytokines.
体外研究：
Ergothioneine (0.25, 1 mM, 23 h) 对过氧化氢诱导的 PC12 DNA 损伤、MAPKs 激活和细胞死亡有调节作用。
产品资料
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