产品
编 号：F369355
分子式：C24H34O3
分子量：370.52
分子式：C24H34O3
分子量：370.52
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CAS No: 49697-38-3
产品详情
生物活性：
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
体内研究：
Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis.Animal Model:Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis
Dosage:5, 25, 50, 150, 250, 450 μg/mouse
Administration:Intraarticular injection, once
Result:Suppressed the arthritis in a dose-dependent manner. Significantly prevented osteophyte formation at 450 and 150 μg. Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
体外研究：
Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy.
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
体内研究：
Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis.Animal Model:Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis
Dosage:5, 25, 50, 150, 250, 450 μg/mouse
Administration:Intraarticular injection, once
Result:Suppressed the arthritis in a dose-dependent manner. Significantly prevented osteophyte formation at 450 and 150 μg. Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
体外研究：
Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy.
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