产品
编 号：F041604
分子式：C17H11N5
分子量：285.3
分子式：C17H11N5
分子量：285.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
520
In-stock
50mg
720
In-stock
100mg
1280
In-stock
200mg
2240
In-stock
500mg
3280
In-stock
结构图
CAS No: 112809-51-5
产品详情
生物活性：
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer.
体内研究：
Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats.Animal Model:Adult female rats bearing mammary tumors
Dosage:3, 10, 30, 100, 300 μg/kg
Administration:Oral gavage once daily for 6 weeks
Result:Induced complete regression of mammary tumors, with an ED50 of 10-30 μg/kg/day.
体外研究：
Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner.Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation.Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells.
Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer.
体内研究：
Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats.Animal Model:Adult female rats bearing mammary tumors
Dosage:3, 10, 30, 100, 300 μg/kg
Administration:Oral gavage once daily for 6 weeks
Result:Induced complete regression of mammary tumors, with an ED50 of 10-30 μg/kg/day.
体外研究：
Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner.Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation.Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells.
产品资料
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