产品
编 号:F368560
分子式:C13H16HgNNaO6
分子量:505.85
产品类型
结构图
CAS No: 492-18-2
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产品详情
生物活性:
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects.
体内研究:
Mersalyl (2.5-40 mg/kg; intramuscularly injection) shows diuresis effects in Rats.Animal Model:Rats
Dosage:2.5-40 mg/kg
Administration:Intramuscularly injection
Result:Significantly depressed in sulfhydryl concentration at 5 mg/kg.
体外研究:
Mersalyl (100 μM) induces VEGF and ENO1 mRNA expression but inhibits EPO mRNA expression induced by hypoxia, DFO, or CoCl2.Mersalyl (20 μM; 5 min) is a cell-impermeant organomercurial compound that reacts with free thiol groups in mitochondrial membrane protein.