产品
编 号：F368447
分子式：C16H12O6
分子量：300.26
分子式：C16H12O6
分子量：300.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
200
In-stock
10mg
352
In-stock
50mg
1200
In-stock
结构图
CAS No: 491-54-3
产品详情
生物活性：
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research.
体内研究：
Kaempferid (25 mg/kg; 静脉注射; 一周三次) 在 SD (Sprague Dawley) 大鼠中具有抗癌活性。Kaempferide (10 mg/kg; 日食喂养,一天一次连续 16 周) 在肥胖 C57BL/6J 小鼠中通过抑制 TLR4/i-κBα/NF-κB 通路来改善氧化应激和炎症，并且可以缓解小鼠的肥胖和糖脂代谢紊乱。Kaempferide (0.1-0.3 mg/kg; 注射; 单剂量) 在缺血/再灌注 (I/R) 诱导的 SD (Sprague Dawley) 大鼠中通过激活 PI3K/Akt/GSK-3β 通路来缓解心肌缺血/再灌注损伤。Animal Model:High-fat diet male C57BL/6J mice model
Dosage:10 mg/kg
Administration:Supplemented in daily diet, once daily for16 weeks
Result:Reduced the weight, organ weight, and index of mice.Lowered the levels of glycolipids in mouse serum.Decreased the expression levels of inflammatory-related genes, including NF-κB, IL-6, ICAM-1, VCAM-1, and TNF-α.
Animal Model:Ischemia/Reperfusion (I/R) SD rat model.
Dosage:0.1 mg/kg, 0.3 mg/kg, 3 mg/kg
Administration:Injection, Single dose. Before the I/R injury induced by Coronary Artery Ligation (CAL) in SD rats.
Result:Significantly improved heart function, reduced myocardial injury by reducing myocardial enzyme levels, and dose-dependently reduced the area of myocardial infarction in rats.Significantly decreased serum levels of TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS, while increasing serum levels of SOD.Downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3, and upregulated the phosphorylation expression levels of phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β).
体外研究：
Kaempferid 在 HCC 细胞系中具有细胞毒性 (HepG2:IC50?=?27.94 μM; Huh7: IC50?=?25.65? μM; N1S1: IC50?=?15.18? μM)。Kaempferid (5, 20 μM; 48 h) 在 HepG2 细胞中减轻 oral acid (OA) (0.5 mM) (HY-N1446) 诱导的细胞脂质积累和氧化应激。Kaempferide 通过 FoxO1/β-catenin 信号通路来促进成骨。Kaempferide (10-15 μM; 24 h) 在 HeLa 细胞中具有细胞毒性 IC50 为 16 μM，且可以诱导细胞凋亡。
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research.
体内研究：
Kaempferid (25 mg/kg; 静脉注射; 一周三次) 在 SD (Sprague Dawley) 大鼠中具有抗癌活性。Kaempferide (10 mg/kg; 日食喂养,一天一次连续 16 周) 在肥胖 C57BL/6J 小鼠中通过抑制 TLR4/i-κBα/NF-κB 通路来改善氧化应激和炎症，并且可以缓解小鼠的肥胖和糖脂代谢紊乱。Kaempferide (0.1-0.3 mg/kg; 注射; 单剂量) 在缺血/再灌注 (I/R) 诱导的 SD (Sprague Dawley) 大鼠中通过激活 PI3K/Akt/GSK-3β 通路来缓解心肌缺血/再灌注损伤。Animal Model:High-fat diet male C57BL/6J mice model
Dosage:10 mg/kg
Administration:Supplemented in daily diet, once daily for16 weeks
Result:Reduced the weight, organ weight, and index of mice.Lowered the levels of glycolipids in mouse serum.Decreased the expression levels of inflammatory-related genes, including NF-κB, IL-6, ICAM-1, VCAM-1, and TNF-α.
Animal Model:Ischemia/Reperfusion (I/R) SD rat model.
Dosage:0.1 mg/kg, 0.3 mg/kg, 3 mg/kg
Administration:Injection, Single dose. Before the I/R injury induced by Coronary Artery Ligation (CAL) in SD rats.
Result:Significantly improved heart function, reduced myocardial injury by reducing myocardial enzyme levels, and dose-dependently reduced the area of myocardial infarction in rats.Significantly decreased serum levels of TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS, while increasing serum levels of SOD.Downregulated the expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3, and upregulated the phosphorylation expression levels of phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β).
体外研究：
Kaempferid 在 HCC 细胞系中具有细胞毒性 (HepG2:IC50?=?27.94 μM; Huh7: IC50?=?25.65? μM; N1S1: IC50?=?15.18? μM)。Kaempferid (5, 20 μM; 48 h) 在 HepG2 细胞中减轻 oral acid (OA) (0.5 mM) (HY-N1446) 诱导的细胞脂质积累和氧化应激。Kaempferide 通过 FoxO1/β-catenin 信号通路来促进成骨。Kaempferide (10-15 μM; 24 h) 在 HeLa 细胞中具有细胞毒性 IC50 为 16 μM，且可以诱导细胞凋亡。
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