产品
编 号：F368227
分子式：C23H32Cl2NO6P
分子量：520.38
分子式：C23H32Cl2NO6P
分子量：520.38
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CAS No: 4891-15-0
产品详情
生物活性：
Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
体内研究：
Estramustine phosphate (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.Animal Model:Human prostate cancer xenograft PAC120
Dosage:4 or 12 mg/kg, a daily dose for 2 weeks.
Administration:Intraperitoneal injection
Result:Inhibited PAC120 tumor growth 53% by day 35.
体外研究：
Estramustine phosphate (1 μg/mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate (2 μg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate (0-40 μM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate (10 μM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation.
Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer.
体内研究：
Estramustine phosphate (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.Animal Model:Human prostate cancer xenograft PAC120
Dosage:4 or 12 mg/kg, a daily dose for 2 weeks.
Administration:Intraperitoneal injection
Result:Inhibited PAC120 tumor growth 53% by day 35.
体外研究：
Estramustine phosphate (1 μg/mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate (2 μg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate (0-40 μM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate (10 μM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation.
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