产品
编 号：F041509
分子式：C32H44O16
分子量：684.68
分子式：C32H44O16
分子量：684.68
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 112747-98-5
产品详情
生物活性：
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
体外研究：
Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV). Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells. Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells. Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus.
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
体外研究：
Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV). Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells. Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells. Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus.
产品资料
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