产品
编 号:F368015
分子式:C15H24O2
分子量:236.35
产品类型
结构图
CAS No: 4871-97-0
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产品详情
生物活性:
Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.
体外研究:
姜黄素 ((-)-Curcumol) 是从姜黄根中提取的主要成分。姜黄素通过下调 CDKL3 对胆管癌细胞发挥抗癌作用。姜黄素通过活性氧和 Akt/GSK3β/cyclin D1 通路诱导结肠癌细胞的细胞周期停滞。姜黄素通过 JNK1/2 和 Akt 依赖性 NF-κB 信号通路抑制 MMP-9 从而抑制乳腺癌细胞转移。