产品
编 号：F368007
分子式：C12H16O3
分子量：208.25
分子式：C12H16O3
分子量：208.25
产品类型
规格
价格
是否有货
100mg
400
In-stock
结构图
CAS No: 487-11-6
产品详情
生物活性：
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity.
体内研究：
Elemicin (500 mg/kg；口服灌胃；每 24 小时一次，持续 3 周) 会损害小鼠的肝功能。Elemicin 抑制肝脏 SCD1，导致溶血磷脂酰胆碱 (LPC) 失衡。Animal Model:Male 20-22 g wild-type C57BL/6J mice
Dosage:500 mg/kg suspended in 0.5% CMC-Na
Administration:Orally gavage; every 24 h for 3 weeks
Result:Significantly increased liver weights, elevated TG levels in plasma and liver, reduced the total plasma GSH and GSSG.
体外研究：
Elemicin (62.5、125、250、500、1000 μM) 在 HepG2 细胞中的 IC50 值为 910 μM。
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity.
体内研究：
Elemicin (500 mg/kg；口服灌胃；每 24 小时一次，持续 3 周) 会损害小鼠的肝功能。Elemicin 抑制肝脏 SCD1，导致溶血磷脂酰胆碱 (LPC) 失衡。Animal Model:Male 20-22 g wild-type C57BL/6J mice
Dosage:500 mg/kg suspended in 0.5% CMC-Na
Administration:Orally gavage; every 24 h for 3 weeks
Result:Significantly increased liver weights, elevated TG levels in plasma and liver, reduced the total plasma GSH and GSSG.
体外研究：
Elemicin (62.5、125、250、500、1000 μM) 在 HepG2 细胞中的 IC50 值为 910 μM。
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