产品
编 号:F367443
分子式:C21H20O12
分子量:464.38
产品类型
结构图
CAS No: 482-36-0
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产品详情
生物活性:
Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.
体内研究:
Hyperoside (腹膜内注射;50 mg/kg;每两天一次,持续 18 天) 处理可抑制体内乳腺肿瘤生长。Animal Model:Balb/c mice injected with 4T1 cells
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; every two day for 18 days
Result:Reduced the average tumor volume compared to the control group.Decreased Bcl-2 and increased bax and cleaved caspase-3.
体外研究:
Hyperoside (12.5-100 μM;6-24 h) 抑制 MCF-7 和 4T1 细胞生长。Hyperoside (25-100 μM;24 h) 诱导乳腺癌细胞凋亡细胞。Hyperoside 通过抑制细胞内 ROS 的产生抑制 NF-κB 信号通路的激活。