产品
编 号：F367376
分子式：C15H10O5
分子量：270.24
分子式：C15H10O5
分子量：270.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
721.6
In-stock
100mg
656
In-stock
500mg
1640
In-stock
结构图
CAS No: 481-72-1
产品详情
生物活性：
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis. Aloe emodin also exhibits antiviral activity that against influenza A virus.
体内研究：
Aloe emodin (10-50 mg/kg) 通过抑制 mTOR 复合物 2 活性来抑制肿瘤生长。Animal Model:Athymic nude mice (BALB/c nude mouse, 6 weeks old)
Dosage:10 mg/kg, 50 mg/kg (20% PEG400 in autoclaved PBS)
Administration:Intraperitoneal injection, five times per week; for 28 days
Result:Exhibited tumor suppression effects in vivo in an athymic nude mouse model.
体外研究：
Aloe emodin （0-15 μM；24-96 小时）以剂量依赖性方式抑制 PC3 细胞增殖。Aloe emodin （0-15 μM；24 小时）抑制 mTORC2 下游底物 Akt 和 PKCα 的激活。Aloe emodin可以与细胞内的 mTORC2 结合并抑制其激酶活性。
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis. Aloe emodin also exhibits antiviral activity that against influenza A virus.
体内研究：
Aloe emodin (10-50 mg/kg) 通过抑制 mTOR 复合物 2 活性来抑制肿瘤生长。Animal Model:Athymic nude mice (BALB/c nude mouse, 6 weeks old)
Dosage:10 mg/kg, 50 mg/kg (20% PEG400 in autoclaved PBS)
Administration:Intraperitoneal injection, five times per week; for 28 days
Result:Exhibited tumor suppression effects in vivo in an athymic nude mouse model.
体外研究：
Aloe emodin （0-15 μM；24-96 小时）以剂量依赖性方式抑制 PC3 细胞增殖。Aloe emodin （0-15 μM；24 小时）抑制 mTORC2 下游底物 Akt 和 PKCα 的激活。Aloe emodin可以与细胞内的 mTORC2 结合并抑制其激酶活性。
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