产品
编 号：F367178
分子式：C31H38ClN7O7S2
分子量：720.26
分子式：C31H38ClN7O7S2
分子量：720.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 480449-71-6
产品详情
生物活性：
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban tosylate (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban tosylate (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban tosylate inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban tosylate (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban tosylate (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban tosylate inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
产品资料
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