产品
编 号：F367177
分子式：C24H30ClN7O4S
分子量：548.06
分子式：C24H30ClN7O4S
分子量：548.06
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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50mg
询价
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100mg
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询价
结构图
CAS No: 480449-70-5
产品详情
生物活性：
Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.
体内研究：
Edoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.
体内研究：
Edoxaban (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
产品资料
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