产品
编 号：F367175
分子式：C24H31Cl2N7O4S
分子量：584.52
分子式：C24H31Cl2N7O4S
分子量：584.52
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CAS No: 480448-29-1
产品详情
生物活性：
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban hydrochloride (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban hydrochloride (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban hydrochloride inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research.
体内研究：
Edoxaban hydrochloride (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.Animal Model:Male Slc: Wistar rats (210-240 g); Male New Zealand White rabbits(2.5-3.5 kg) (Both are venous stasis thrombosis model).
Dosage:0.5, 2.5 and 12.5 mg/kg
Administration:Oral administration; once
Result:Inhibited exogenous FXa activity.Antithrombotic.
体外研究：
Edoxaban hydrochloride (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.Edoxaban hydrochloride inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 μM.
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