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编 号：F367005
分子式：C16H17N3O4
分子量：315.32
分子式：C16H17N3O4
分子量：315.32
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CAS No: 4803-27-4
产品详情
生物活性：
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.
体内研究：
Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice.Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart.Animal Model:Male ddY mice (20 ± 2 g, 12-14 each group)
Dosage:0, 0.3, and 0.5 mg/kg
Administration:IP, once, 10 min before the intracisternal (i.c.) injection of CCK
Result:Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
Animal Model:Female CFN Gif rats (140-180 g)
Dosage:0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
Administration:SC, daily for 8 days
Result:Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
体外研究：
ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC.Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria.
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.
体内研究：
Anthramycin (0-0.5 mg/kg, IP, once) has potent anti-CCK (cholecystokinin) activity and antinociceptive effects in the central nervous system in mice.Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart.Animal Model:Male ddY mice (20 ± 2 g, 12-14 each group)
Dosage:0, 0.3, and 0.5 mg/kg
Administration:IP, once, 10 min before the intracisternal (i.c.) injection of CCK
Result:Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
Animal Model:Female CFN Gif rats (140-180 g)
Dosage:0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
Administration:SC, daily for 8 days
Result:Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
体外研究：
ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC.Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria.
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