产品
编 号：F367001
分子式：C15H10O6
分子量：286.24
分子式：C15H10O6
分子量：286.24
产品类型
规格
价格
是否有货
1mg
询价
询价
2mg
询价
询价
5mg
询价
询价
结构图
CAS No: 480-23-9
产品详情
生物活性：
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ).
体内研究：
Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice.Animal Model:HFD-induced obesity in C57BL/6J mice
Dosage:10?mg/kg
Administration:Intragastrically; daily for 23 weeks
Result:Significantly reduced body weight by 17.3% compared to the HFD group.
体外研究：
Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon.Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1.
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ).
体内研究：
Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice.Animal Model:HFD-induced obesity in C57BL/6J mice
Dosage:10?mg/kg
Administration:Intragastrically; daily for 23 weeks
Result:Significantly reduced body weight by 17.3% compared to the HFD group.
体外研究：
Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon.Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1.
产品资料
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