产品
编 号：F366980
分子式：C15H22O9
分子量：346.33
分子式：C15H22O9
分子量：346.33
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 479-98-1
产品详情
生物活性：
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.
体内研究：
Aucubin (5 mg/kg/d；腹腔注射；15 d) 对链脲佐菌素诱导的糖尿病大鼠具有抗氧化和胰腺保护作用。 Aucubin (40-200 mg/kg；腹腔注射，单剂量) 对小鼠 α-amanitin 中毒具有显著的保护作用。Aucubin (5 mg/kg/d；腹腔注射；21 天) 降低呼吸频率，增加 BLM 刺激小鼠肺动态顺应性，减轻肺实质纤维化改变，减轻肺内胶原沉积和炎症损伤。Animal Model:Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin
Dosage:5 mg/kg
Administration:I.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days
Result:Increased the body weight of streptozotocin-diabetic rats.Lowered the blood glucose level.Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes.Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.
体外研究：
Aucubin (0.001-1 μg/mL；预处理 30 分钟) 剂量依赖性地抑制 RBL-2H3 细胞中 IgE 诱导的 TNF-α 和 IL-6 的产生和表达，IC50 为 0.101和 0.19 μg/mL。 Aucubin (0.01 μg/mL；预处理 30 分钟) 抑制 IgE 诱导的 NF-κB p65 亚基核转位和降解RBL-2H3 细胞中的 IκBα。 Aucubin (0.001-1 mM；12 h) 增加 PC12 细胞活力并显著抑制 H2O2诱导的细胞凋亡。
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.
体内研究：
Aucubin (5 mg/kg/d；腹腔注射；15 d) 对链脲佐菌素诱导的糖尿病大鼠具有抗氧化和胰腺保护作用。 Aucubin (40-200 mg/kg；腹腔注射，单剂量) 对小鼠 α-amanitin 中毒具有显著的保护作用。Aucubin (5 mg/kg/d；腹腔注射；21 天) 降低呼吸频率，增加 BLM 刺激小鼠肺动态顺应性，减轻肺实质纤维化改变，减轻肺内胶原沉积和炎症损伤。Animal Model:Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin
Dosage:5 mg/kg
Administration:I.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days
Result:Increased the body weight of streptozotocin-diabetic rats.Lowered the blood glucose level.Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes.Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.
体外研究：
Aucubin (0.001-1 μg/mL；预处理 30 分钟) 剂量依赖性地抑制 RBL-2H3 细胞中 IgE 诱导的 TNF-α 和 IL-6 的产生和表达，IC50 为 0.101和 0.19 μg/mL。 Aucubin (0.01 μg/mL；预处理 30 分钟) 抑制 IgE 诱导的 NF-κB p65 亚基核转位和降解RBL-2H3 细胞中的 IκBα。 Aucubin (0.001-1 mM；12 h) 增加 PC12 细胞活力并显著抑制 H2O2诱导的细胞凋亡。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备