产品
编 号：F366879
分子式：C23H40N2O3
分子量：392.58
分子式：C23H40N2O3
分子量：392.58
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
275
In-stock
10mg
440
In-stock
50mg
1280
In-stock
100mg
2048
In-stock
250mg
询价
询价
结构图
CAS No: 479413-70-2
产品详情
生物活性：
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.
体内研究：
AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g)
Dosage:10 mg/kg
Administration:i.p.; 14 days
Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.
体外研究：
AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs.
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively. AUDA has anti-inflammatory activity.
体内研究：
AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g)
Dosage:10 mg/kg
Administration:i.p.; 14 days
Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.
体外研究：
AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs.
产品资料
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