产品
编 号：F366861
分子式：C12H6N4Na2O6S
分子量：380.24
分子式：C12H6N4Na2O6S
分子量：380.24
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CAS No: 479347-86-9
产品详情
生物活性：
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
体内研究：
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion. Animal Model:Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)
Dosage:20 mg/kg
Administration:IP; for 3 days
Result:Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
体外研究：
NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
体内研究：
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion. Animal Model:Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)
Dosage:20 mg/kg
Administration:IP; for 3 days
Result:Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
体外研究：
NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
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