产品
编 号：F366438
分子式：C12H13NO4
分子量：235.24
分子式：C12H13NO4
分子量：235.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 478336-92-4
产品详情
生物活性：
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
体内研究：
ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect.ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants.Animal Model: C57Bl/6 MIF+/+ and MIF–/– mice
Dosage:3.5-35 mg/kg
Administration:Injected intraperitoneally;3.5-35 mg/kg; twice a day ; 2 weeks
Result:Was protective against lethal sepsis.
Animal Model:Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice
Dosage:35 mg/kg
Administration:Intraperitoneal injection; 35 mg/kg; twice daily; 3 days
Result:Reduced average endometriotic implant size.
体外研究：
ISO-1 (0.1-20 μM; 16 hours) has a slight inhibitory effect on Cox-2 secretion without the addition of recombinant MIF.
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
体内研究：
ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect.ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants.Animal Model: C57Bl/6 MIF+/+ and MIF–/– mice
Dosage:3.5-35 mg/kg
Administration:Injected intraperitoneally;3.5-35 mg/kg; twice a day ; 2 weeks
Result:Was protective against lethal sepsis.
Animal Model:Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice
Dosage:35 mg/kg
Administration:Intraperitoneal injection; 35 mg/kg; twice daily; 3 days
Result:Reduced average endometriotic implant size.
体外研究：
ISO-1 (0.1-20 μM; 16 hours) has a slight inhibitory effect on Cox-2 secretion without the addition of recombinant MIF.
产品资料
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