产品
编 号：F366177
分子式：C15H17N3O2
分子量：271.31
分子式：C15H17N3O2
分子量：271.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 478149-53-0
产品详情
生物活性：
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
体内研究：
PHA-543613 (0.3 mg/kg) 成功逆转 Scopolamine 诱导的大鼠短期记忆缺陷。 PHA-543613 (4 和 12 mg/kg；ip 一次) 减少行为缺陷和脑水肿。Animal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery
Dosage:4 and 12 mg/kg
Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits andbrain edema at 72 hours after ICH.
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
体内研究：
PHA-543613 (0.3 mg/kg) 成功逆转 Scopolamine 诱导的大鼠短期记忆缺陷。 PHA-543613 (4 和 12 mg/kg；ip 一次) 减少行为缺陷和脑水肿。Animal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery
Dosage:4 and 12 mg/kg
Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits andbrain edema at 72 hours after ICH.
产品资料
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