产品
编 号：F365674
分子式：C21H22O8
分子量：402.39
分子式：C21H22O8
分子量：402.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
272
In-stock
5mg
600
In-stock
10mg
880
In-stock
50mg
2640
In-stock
100mg
4080
In-stock
200mg
6960
In-stock
结构图
CAS No: 478-01-3
产品详情
生物活性：
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.
体内研究：
Nobiletin (常规饮食的 0.1%；口服给药；每天；持续 20 周；雄性 C57BL/6 小鼠) 处理可恢复老年小鼠的葡萄糖稳态并促进能量消耗和昼夜节律活动。Animal Model:20- to 22-month-old male C57BL/6 mice
Dosage:0.1% of regular diet
Administration:Oral administration; daily; for 20 weeks
Result:Fully restored glucose tolerance in aged mice, and increased basal body temperature and cold tolerance in aged mice. Led to a twofold increase in distance run/day on voluntary wheels compared with aged regular diet-fed mice during the active phase.
体外研究：
Nobiletin (0-100 μM；24 小时；U2OS 和 HOS 细胞) 处理逐渐降低 MMP-2 和 MMP-9 的蛋白表达。在 U2OS 和 HOS 细胞中，Nobiletin 显著降低 p-IKKα/β 和 p-IκBα 的磷酸化，以及细胞核部分中 NF-κB 的蛋白表达，同时增加胞质部分中的 NF-κB 表达。Nobiletin 下调细胞核中p-CREB 和SP-1 的表达，而Nobiletin 不影响c-Jun 和c-Fos 的表达。 Nobiletin (0-100 μM；24 小时；U2OS 和 HOS 细胞) 处理显著降低 U2OS 和 HOS 细胞中 MMP-2 和 MMP-9 的 mRNA 表达，且呈剂量依赖性。
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis.
体内研究：
Nobiletin (常规饮食的 0.1%；口服给药；每天；持续 20 周；雄性 C57BL/6 小鼠) 处理可恢复老年小鼠的葡萄糖稳态并促进能量消耗和昼夜节律活动。Animal Model:20- to 22-month-old male C57BL/6 mice
Dosage:0.1% of regular diet
Administration:Oral administration; daily; for 20 weeks
Result:Fully restored glucose tolerance in aged mice, and increased basal body temperature and cold tolerance in aged mice. Led to a twofold increase in distance run/day on voluntary wheels compared with aged regular diet-fed mice during the active phase.
体外研究：
Nobiletin (0-100 μM；24 小时；U2OS 和 HOS 细胞) 处理逐渐降低 MMP-2 和 MMP-9 的蛋白表达。在 U2OS 和 HOS 细胞中，Nobiletin 显著降低 p-IKKα/β 和 p-IκBα 的磷酸化，以及细胞核部分中 NF-κB 的蛋白表达，同时增加胞质部分中的 NF-κB 表达。Nobiletin 下调细胞核中p-CREB 和SP-1 的表达，而Nobiletin 不影响c-Jun 和c-Fos 的表达。 Nobiletin (0-100 μM；24 小时；U2OS 和 HOS 细胞) 处理显著降低 U2OS 和 HOS 细胞中 MMP-2 和 MMP-9 的 mRNA 表达，且呈剂量依赖性。
产品资料
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