产品
编 号：F364920
分子式：C19H21NO4
分子量：327.37
分子式：C19H21NO4
分子量：327.37
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 476-70-0
产品详情
生物活性：
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
体内研究：
Boldine (50 mg/kg, 口服, 连续7天) 在小鼠中通过 p65-NF-κB 和 STAT3 信号通路减弱 Dextran Sulfate Sodium (DSS) 诱导的结肠炎。Animal Model:DSS-induced mice model
Dosage:50 mg/kg
Administration:p.o.
Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.
体外研究：
Boldine (10-500 μM, 24 h) 抑制 T24 人膀胱癌细胞生长sup>。Boldine (200, 400 μM, 24 h) 通过调控 ERK、 AKT 和 GSK-3β 诱导 T24 人膀胱癌细胞 G2/M 期阻滞和细胞凋亡。
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
体内研究：
Boldine (50 mg/kg, 口服, 连续7天) 在小鼠中通过 p65-NF-κB 和 STAT3 信号通路减弱 Dextran Sulfate Sodium (DSS) 诱导的结肠炎。Animal Model:DSS-induced mice model
Dosage:50 mg/kg
Administration:p.o.
Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.
体外研究：
Boldine (10-500 μM, 24 h) 抑制 T24 人膀胱癌细胞生长sup>。Boldine (200, 400 μM, 24 h) 通过调控 ERK、 AKT 和 GSK-3β 诱导 T24 人膀胱癌细胞 G2/M 期阻滞和细胞凋亡。
产品资料
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