产品
编 号：F364782
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规格
价格
是否有货
1mg
询价
询价
5mg
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CAS No: 476181-74-5
产品详情
生物活性：
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.
体内研究：
Golimumab (CNTO-148) (24 mg/kg; i.h.; daily, for 7 days; swiss-albino healthy male mice) inhibits oxidative stress, apoptotic cell death inflammatory response, thus improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death.Golimumab (CNTO-148) (1-10 mg/kg; i.p.;daily; for 4 weeks; Tg197 transgenic mouse model) relieves TNFα-induced arthritis in a mouse model of human.Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Reduced serum parameters like BUN, NGAL creatinine, cystatin C, and urinary parameters like KIM-1, NAG, albumin clusterin.
Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Inhibited oxidative stress, reduces MDA concentrations and increases the GSH and catalase levels.
Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Inhibitd cisplatin-induced inflammation, decreased TNF-α, including IL-6, IL-1β, MCP-1, ICAM-1, and TGF-β1 levels and increases IL-10 concentrations, reduced caspase 3 in cisplatin injected mice kidneys.
Animal Model:Tg197 transgenic mouse model
Dosage:1 and 10 mg/kg
Administration:Intraperitoneal injection;for 4 weeks
Result:Reduced the arthritic index.
体外研究：
Golimumab (CNTO-148) (0.1-10 μg /mL; 24-72 hours; transmembrane TNFα–transfected Jurkat cells) induces reductions in the viability of transmembrane TNFα–expressing cells.Golimumab (CNTO-148) (10 μg /mL; 48 hours; transmembrane TNFα–transfected Jurkat cells) induces apoptosis, increase the levels of active caspase-3 and induces apoptotic DNA fragmentation.
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research.
体内研究：
Golimumab (CNTO-148) (24 mg/kg; i.h.; daily, for 7 days; swiss-albino healthy male mice) inhibits oxidative stress, apoptotic cell death inflammatory response, thus improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death.Golimumab (CNTO-148) (1-10 mg/kg; i.p.;daily; for 4 weeks; Tg197 transgenic mouse model) relieves TNFα-induced arthritis in a mouse model of human.Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Reduced serum parameters like BUN, NGAL creatinine, cystatin C, and urinary parameters like KIM-1, NAG, albumin clusterin.
Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Inhibited oxidative stress, reduces MDA concentrations and increases the GSH and catalase levels.
Animal Model:Swiss-albino healthy male mice
Dosage:24 mg/kg
Administration:Subcutaneous injection; daily, for 7 days
Result:Inhibitd cisplatin-induced inflammation, decreased TNF-α, including IL-6, IL-1β, MCP-1, ICAM-1, and TGF-β1 levels and increases IL-10 concentrations, reduced caspase 3 in cisplatin injected mice kidneys.
Animal Model:Tg197 transgenic mouse model
Dosage:1 and 10 mg/kg
Administration:Intraperitoneal injection;for 4 weeks
Result:Reduced the arthritic index.
体外研究：
Golimumab (CNTO-148) (0.1-10 μg /mL; 24-72 hours; transmembrane TNFα–transfected Jurkat cells) induces reductions in the viability of transmembrane TNFα–expressing cells.Golimumab (CNTO-148) (10 μg /mL; 48 hours; transmembrane TNFα–transfected Jurkat cells) induces apoptosis, increase the levels of active caspase-3 and induces apoptotic DNA fragmentation.
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