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编 号:F364686
分子式:C34H39N7O4
分子量:609.72
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1mg
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5mg
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10mg
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生物活性:
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake.

体内研究:
MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice.MCL0020 significantly reverses stress-induced anorexia in rats.

体外研究:
MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63.
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