产品
编 号：F364475
分子式：C21H22ClN3O
分子量：367.87
分子式：C21H22ClN3O
分子量：367.87
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CAS No: 47491-38-3
产品详情
生物活性：
Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
体内研究：
1.19Pharmacokinetic parameters of desmethylazelastine after a single oral administration of 1.0 mg/kg azelastine hydrochloride in guinea pigs.Blood Lung
Cmax (ng/mL)[a]17.62863
Tmax (h)3.0-6.04.0-6.0
Tlag (h)0.250.39
AUC0-24 (ng?h/mL)[a]18028502
t1/2 (h)4.243.90
CL (L/h)0.213
Lung-blood ratio[b]146146
[a] For lung, the unit in grams (g) instead of milliliter (mL).[b] Mean value calculated from all time points.
Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
体内研究：
1.19Pharmacokinetic parameters of desmethylazelastine after a single oral administration of 1.0 mg/kg azelastine hydrochloride in guinea pigs.Blood Lung
Cmax (ng/mL)[a]17.62863
Tmax (h)3.0-6.04.0-6.0
Tlag (h)0.250.39
AUC0-24 (ng?h/mL)[a]18028502
t1/2 (h)4.243.90
CL (L/h)0.213
Lung-blood ratio[b]146146
[a] For lung, the unit in grams (g) instead of milliliter (mL).[b] Mean value calculated from all time points.
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