产品
编 号：F364388
分子式：C28H46O
分子量：398.66
分子式：C28H46O
分子量：398.66
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 474-67-9
产品详情
生物活性：
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease.
体外研究：
Brassicasterol (10 μM; 24 h) 下调二氢睾酮 (DHT) 诱导的 LNCaP 细胞中雄激素受体 (AR) 和前列腺特异性抗原 (PSA) 的表达。Brassicasterol (50 μM; 48 h) 将 LNCaP 的细胞周期阻滞在亚 G1 期，并诱导细胞凋亡。Brassicasterol (10 μM; 48 h) 还抑制 LNCaP 细胞迁移。Brassicasterol (100 μg/mL; 48 h) 在 3D 类器官模型中，能够抑制 AKT，并对 AR 不依赖的癌症以及 AR 依赖的细胞其抑制效力。
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease.
体外研究：
Brassicasterol (10 μM; 24 h) 下调二氢睾酮 (DHT) 诱导的 LNCaP 细胞中雄激素受体 (AR) 和前列腺特异性抗原 (PSA) 的表达。Brassicasterol (50 μM; 48 h) 将 LNCaP 的细胞周期阻滞在亚 G1 期，并诱导细胞凋亡。Brassicasterol (10 μM; 48 h) 还抑制 LNCaP 细胞迁移。Brassicasterol (100 μg/mL; 48 h) 在 3D 类器官模型中，能够抑制 AKT，并对 AR 不依赖的癌症以及 AR 依赖的细胞其抑制效力。
产品资料
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