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编 号:F364244
分子式:C16H14O5
分子量:286.28
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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20mg
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生物活性:
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.

体内研究:
Brazilin(10 mg/kg,i.p,28 d)可减轻成年小鼠 CMS 诱导的抑郁和焦虑样行为[4。Animal Model:Chronic mild stress (CMS) mice model
Dosage:10 mg/kg
Administration:Intraperitoneally injected (i.p.), once a day for 28 d
Result:Decreased the prolonged latency to feeding significantly.

体外研究:
Brazilin(40 μM,24 h)对 PC12 细胞没有显着的细胞毒性作用。Brazilin(10 μM,1 h)可减少 H2O2 诱导的(200 μM,24 h) PC12 细胞中的细胞毒性。Brazilin(10 μM,1 h)拮抗剂 H2O2 诱导的(200 μM,24 小时)PC12 细胞中的细胞毒性。
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