产品
编 号：F363960
分子式：C15H26O
分子量：222.37
分子式：C15H26O
分子量：222.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 473-15-4
产品详情
生物活性：
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea.
体内研究：
Beta-Eudesmol (2.5-5 mg/kg; 腹腔注射; 每天一次连续7天) 在 MK 小鼠中显著抑制肿瘤细胞和新血管的生成。Beta-Eudesmol (50-100 mg/kg; 腹腔注射; 单剂量) 在 C57BL/6 小鼠中能够抑制 NF-κb 信号通路，具有抗炎抗氧化作用。Animal Model:Male KM mice model
Dosage:1.25 mg/kg, 2.5mg/kg, 5 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 7 days
Result:Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively.Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively.Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg).
Animal Model: Male C57BL/6 mice model
Dosage:50 mg/kg, 100 mg/kg
Administration:Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation.
Result:Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner.Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO).Inhibit the phosphorylation of p65.
体外研究：
Beta-Eudesmol (30-100 μM; 6 天) 在 HUVEC 细胞中能够抑制血管内皮生长因子 (VEGF) (30 ng/ml) 和碱性成纤维细胞生长因子 (bFGF) (30 ng/ml) 诱导的细胞增殖，从而抑制血管生成。Beta-Eudesmol (10-100 μM; 72 小时) 在肿瘤细胞 HeLa、SGC-7901 和 BEL-7402 中以时间和剂量依赖方式抑制细胞增殖。Beta-Eudesmol (10-120 μM; 4 小时) 在 HL-60 细胞中可以降低细胞活性。Beta-Eudesmol (40-80 μM; 4 小时) 在 HL-60 细胞中能通过诱导细胞色素 c 的释放激活 caspase-3，从而诱导细胞凋亡。
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea.
体内研究：
Beta-Eudesmol (2.5-5 mg/kg; 腹腔注射; 每天一次连续7天) 在 MK 小鼠中显著抑制肿瘤细胞和新血管的生成。Beta-Eudesmol (50-100 mg/kg; 腹腔注射; 单剂量) 在 C57BL/6 小鼠中能够抑制 NF-κb 信号通路，具有抗炎抗氧化作用。Animal Model:Male KM mice model
Dosage:1.25 mg/kg, 2.5mg/kg, 5 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 7 days
Result:Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively.Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively.Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg).
Animal Model: Male C57BL/6 mice model
Dosage:50 mg/kg, 100 mg/kg
Administration:Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation.
Result:Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner.Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO).Inhibit the phosphorylation of p65.
体外研究：
Beta-Eudesmol (30-100 μM; 6 天) 在 HUVEC 细胞中能够抑制血管内皮生长因子 (VEGF) (30 ng/ml) 和碱性成纤维细胞生长因子 (bFGF) (30 ng/ml) 诱导的细胞增殖，从而抑制血管生成。Beta-Eudesmol (10-100 μM; 72 小时) 在肿瘤细胞 HeLa、SGC-7901 和 BEL-7402 中以时间和剂量依赖方式抑制细胞增殖。Beta-Eudesmol (10-120 μM; 4 小时) 在 HL-60 细胞中可以降低细胞活性。Beta-Eudesmol (40-80 μM; 4 小时) 在 HL-60 细胞中能通过诱导细胞色素 c 的释放激活 caspase-3，从而诱导细胞凋亡。
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