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编 号:F363935
分子式:C13H24N6O4
分子量:328.37
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生物活性:
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

体外研究:
GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release. GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction.GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells. GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3.
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