产品
编 号：F363915
分子式：C20H15NO3
分子量：317.34
分子式：C20H15NO3
分子量：317.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
200
In-stock
5mg
400
In-stock
10mg
480
In-stock
50mg
1600
In-stock
100mg
2800
In-stock
200mg
4760
In-stock
结构图
CAS No: 4727-31-5
产品详情
生物活性：
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research.
体内研究：
Kartogenin（10 μM，溶于 4μL 盐水中；在第 7 天和第 21 天处理）可促进胶原酶 VII 诱导的小鼠 OA 模型中的软骨修复。
体外研究：
Kartogenin（100 nM；72 h）诱导原代 hMSC 中软骨细胞结节的形成。Kartogenin（10 nM-10 μM；72 h）可增加 hMSC 中软骨细胞特异性基因的表达。Kartogenin（0.12-10 μM；48 h）可抑制原代牛关节软骨细胞中细胞因子诱导的一氧化氮 (NO) 和糖胺聚糖 (GAG) 释放。Kartogenin（50-5000 nM；2 wk）以浓度依赖性方式诱导 BMSC 的软骨分化。
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research.
体内研究：
Kartogenin（10 μM，溶于 4μL 盐水中；在第 7 天和第 21 天处理）可促进胶原酶 VII 诱导的小鼠 OA 模型中的软骨修复。
体外研究：
Kartogenin（100 nM；72 h）诱导原代 hMSC 中软骨细胞结节的形成。Kartogenin（10 nM-10 μM；72 h）可增加 hMSC 中软骨细胞特异性基因的表达。Kartogenin（0.12-10 μM；48 h）可抑制原代牛关节软骨细胞中细胞因子诱导的一氧化氮 (NO) 和糖胺聚糖 (GAG) 释放。Kartogenin（50-5000 nM；2 wk）以浓度依赖性方式诱导 BMSC 的软骨分化。
产品资料
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