产品
编 号：F363903
分子式：C40H52O4
分子量：596.84
分子式：C40H52O4
分子量：596.84
产品类型
规格
价格
是否有货
1mg
200
In-stock
5mg
400
In-stock
10mg
560
In-stock
结构图
CAS No: 472-61-7
产品详情
生物活性：
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.
体内研究：
Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats.Animal Model:Nude mice (approximately 20 g; DU145 tumor xenografts model).
Dosage:200 mg/kg
Administration:Intragastric administration; once daily for 3 weeks.
Result:Exerted a significant inhibitory effect on tumor growth.
Animal Model:Female C57BL/6 mice (7 weeks old).
Dosage:125 or 500 mg/kg
Administration:In animal feedings; 7 days.
Result:Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively. Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
体外研究：
Astaxanthin (50, 100, 150, 200 μM; 48 h) inhibits the proliferation of DU145 cells (IC50Astaxanthin 相关抗体:Apoptosis AnalysisCell Line:DU145 cells
Concentration:200 μM (pre-incubation)
Incubation Time:24 h
Result:Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).
Cell Migration Assay Cell Line:DU145 cells
Concentration:200 μM
Incubation Time:24 h
Result:Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).
Cell Proliferation AssayCell Line:ARPE-19 cells
Concentration:50 μM (pre-incubation)
Incubation Time:7 days
Result:Significantly decreased cell proliferation exposed to high glucose.
Western Blot AnalysisCell Line:DU145 cells
Concentration:200 μM
Incubation Time:24 h
Result:Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).
Western Blot AnalysisCell Line:K562 cells
Concentration:1-50 μM
Incubation Time:72 h
Result:Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.
体内研究：
Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats.Animal Model:Nude mice (approximately 20 g; DU145 tumor xenografts model).
Dosage:200 mg/kg
Administration:Intragastric administration; once daily for 3 weeks.
Result:Exerted a significant inhibitory effect on tumor growth.
Animal Model:Female C57BL/6 mice (7 weeks old).
Dosage:125 or 500 mg/kg
Administration:In animal feedings; 7 days.
Result:Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively. Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
体外研究：
Astaxanthin (50, 100, 150, 200 μM; 48 h) inhibits the proliferation of DU145 cells (IC50Astaxanthin 相关抗体:Apoptosis AnalysisCell Line:DU145 cells
Concentration:200 μM (pre-incubation)
Incubation Time:24 h
Result:Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).
Cell Migration Assay Cell Line:DU145 cells
Concentration:200 μM
Incubation Time:24 h
Result:Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).
Cell Proliferation AssayCell Line:ARPE-19 cells
Concentration:50 μM (pre-incubation)
Incubation Time:7 days
Result:Significantly decreased cell proliferation exposed to high glucose.
Western Blot AnalysisCell Line:DU145 cells
Concentration:200 μM
Incubation Time:24 h
Result:Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).
Western Blot AnalysisCell Line:K562 cells
Concentration:1-50 μM
Incubation Time:72 h
Result:Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备