产品
编 号：F363825
分子式：C21H21ClF2O4S
分子量：442.9
分子式：C21H21ClF2O4S
分子量：442.9
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 471905-41-6
产品详情
生物活性：
MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.
体内研究：
MK-0752 (60-240 mg/kg; p.o.) 减少恒河猴大脑中新的 Aβ 的生成。Animal Model:Male rhesus monkeys
Dosage:60-240 mg/kg
Administration:P.o.
Result:Generation of new Aβ was partially blocked with administration of 60 mg/kg, and nearly completely blocked at the 240 mg/kg dose as indicated by the dose-dependent decrease in the amount of 13C6-leucine-labeled Aβ.
MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.
体内研究：
MK-0752 (60-240 mg/kg; p.o.) 减少恒河猴大脑中新的 Aβ 的生成。Animal Model:Male rhesus monkeys
Dosage:60-240 mg/kg
Administration:P.o.
Result:Generation of new Aβ was partially blocked with administration of 60 mg/kg, and nearly completely blocked at the 240 mg/kg dose as indicated by the dose-dependent decrease in the amount of 13C6-leucine-labeled Aβ.
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