产品
编 号：F363356
分子式：C20H20ClF5N2O
分子量：434.83
分子式：C20H20ClF5N2O
分子量：434.83
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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2mg
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5mg
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10mg
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50mg
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结构图
CAS No: 467458-02-2
产品详情
生物活性：
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders.
体内研究：
Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) hydrochloride can reduce food intake and body weight in over-eating rat models.Idalopirdine (1 or 2?mg/kg, i.v) hydrochloride can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats.Animal Model:Male Wistar rats
Dosage:5?mg/kg
Administration:intraperitoneal injection, daily, 28 days
Result:Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol.
Animal Model:Male Sprague-Dawley rats
Dosage:1 or 2?mg/kg
Administration:i.v.
Result:No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg.Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration.
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders.
体内研究：
Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) hydrochloride can reduce food intake and body weight in over-eating rat models.Idalopirdine (1 or 2?mg/kg, i.v) hydrochloride can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats.Animal Model:Male Wistar rats
Dosage:5?mg/kg
Administration:intraperitoneal injection, daily, 28 days
Result:Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol.
Animal Model:Male Sprague-Dawley rats
Dosage:1 or 2?mg/kg
Administration:i.v.
Result:No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg.Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration.
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