产品
编 号：F362970
分子式：C27H32O8
分子量：484.54
分子式：C27H32O8
分子量：484.54
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 4643-58-7
产品详情
生物活性：
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL.
体内研究：
Verrucarin J (0.5?mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis.Animal Model:6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts
Dosage:0.5?mg/kg body weight
Administration:i.p. for 4 weeks
Result:Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.
Animal Model:Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts
Dosage:0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:i.p. for three weeks after 10 days of injection of A2780 cells
Result:Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg.Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg.In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.
体外研究：
Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC50 values of approximately 10 nM and 20 nM after 48 h of treatment, respectively.Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC50 of 300 nM for HCT 116 and SW-620 cell proliferation.Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells.Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei.Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe.Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC50) of 8.2 ng/mL.
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL.
体内研究：
Verrucarin J (0.5?mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis.Animal Model:6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts
Dosage:0.5?mg/kg body weight
Administration:i.p. for 4 weeks
Result:Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.
Animal Model:Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts
Dosage:0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:i.p. for three weeks after 10 days of injection of A2780 cells
Result:Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg.Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg.In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.
体外研究：
Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC50 values of approximately 10 nM and 20 nM after 48 h of treatment, respectively.Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC50 of 300 nM for HCT 116 and SW-620 cell proliferation.Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells.Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei.Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe.Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC50) of 8.2 ng/mL.
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