产品
编 号:F362015
分子式:C10H12N5Na2O7P
分子量:391.18
产品类型
结构图
CAS No: 4578-31-8
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产品详情
生物活性:
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
体内研究:
Adenosine 5'-monophosphate (10 和 13 mg/L,添加在蒸馏水中,25 周) disodium 改善 HFD 诱导的糖尿病小鼠的葡萄糖代谢。Adenosine 5'-monophosphate (40-800 mg/kg,i.p.) disodium 通过小鼠体内的腺苷受体降低体温。Animal Model:C57BL/6 J mice with high-fat diet-induced diabetes
Dosage:10 and 13 mg/L
Administration:Added in distilled water, for 25 weeks
Result:Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.