产品
编 号：F360755
分子式：C15H10F6N2O3
分子量：380.24
分子式：C15H10F6N2O3
分子量：380.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 448895-37-2
产品详情
生物活性：
NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells.
体内研究：
NS1643 (6 mg/kg；腹腔注射，每周两次) 抑制乳腺肿瘤转移。Animal Model:NSG mice with human-derived TNBC tumor xenografts
Dosage:6 mg/kg
Administration:Intraperitoneal injection; 6 mg/kg; twice per week
Result:Significantly reduceed tumor growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).
体外研究：
NS1643 (0-100 μM) 剂量和电压依赖性增加卵母细胞中 hERG 电流。NS1643( 3，10 和 30 μM) 在测试电压范围内减缓了 hERG 失活的速度，降低了 hERG 通道的整流程度。NS1643 (10 和 50 μM) 剂量依赖性地抑制 MDA-MB-231 和 SKBR3 癌细胞的迁移和侵袭。
NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells.
体内研究：
NS1643 (6 mg/kg；腹腔注射，每周两次) 抑制乳腺肿瘤转移。Animal Model:NSG mice with human-derived TNBC tumor xenografts
Dosage:6 mg/kg
Administration:Intraperitoneal injection; 6 mg/kg; twice per week
Result:Significantly reduceed tumor growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).
体外研究：
NS1643 (0-100 μM) 剂量和电压依赖性增加卵母细胞中 hERG 电流。NS1643( 3，10 和 30 μM) 在测试电压范围内减缓了 hERG 失活的速度，降低了 hERG 通道的整流程度。NS1643 (10 和 50 μM) 剂量依赖性地抑制 MDA-MB-231 和 SKBR3 癌细胞的迁移和侵袭。
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